Aminooxyamide tricyclic inhibitors of farnesyl-protein transfera

Details Aminooxyamide tricyclic inhibitors of farnesyl-protein transfera Aminooxyamide tricyclic inhibitors of farnesyl-protein transfera

1998-06-15

1999-08-31

Huang, Evelyn Mei

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 93, A61K 3144, C07D40104, C07D40114

Patent

active

059454300

ABSTRACT:
Novel aminooxyamide tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.

REFERENCES:
patent: 5438062 (1995-08-01), Piwinski et al.
patent: 5665726 (1997-09-01), Piwinski et al.
patent: 5696121 (1997-12-01), Bishop
Khosravi-Far R et al. Cell Growth & Differentiation. 3, 461-9, Jul. 1992.

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