Platenolide synthase gene

Details Platenolide synthase gene Platenolide synthase gene

1997-02-21

1999-08-31

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 691, 4352523, 43525235, 4353201, 530350, 536 232, C12N 900, C12N 1552, C12N 1563, C12N 1576

Patent

active

059453206

ABSTRACT:
A DNA molecule isolated from Streptomyces ambofaciens encodes the multi-functional proteins which direct the synthesis of the polyketide platenolide.

REFERENCES:
patent: 5098837 (1992-03-01), Beckmann et al.
patent: 5252474 (1993-10-01), Gewain et al.
patent: 5614619 (1997-03-01), Piepersberg et al.
patent: 5639949 (1997-06-01), Ligon et al.
patent: 5643774 (1997-07-01), Ligon et al.
patent: 5662898 (1997-09-01), Ligon et al.
David A. Hopwood and David H. Sherman, "Molecular Genetics of Polyketides and its Comparison to Fatty Acid Biosynthesis," Annu. Rev. Genet., 24:37-66 (1990).
Stefano Donadio and Leonard Katz, "Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea," Gene, 111:51-60 (1992).
Jesus Cortes, et al., "Repositioning of a Domain in Modular Polyketide Synthase to Promote Specific Chain Cleavage," Science, 268:1487-1489 (1995).
Stefano Donadio, et al., "Modular Organization of Genes Required for Complex Polyketide Biosynthesis," Science, 252:675-679 (1991).
M. A. Richardson, et al., "Cloning of Spiramycin Biosynthetic Genes and Their Use in Constructing Streptomyces ambofaciens Mutants Defective in Spiramycin Biosynthesis," Journal of Bacteriology, vol. 172, No. 7, 3790-3798 (1990).
Robert J. Beckmann, Karen Cox, and Eugene T. Seno, "A Cluster of Tylosin Biosynthetic Genes Is Interrupted by a Structurally Unstable Segment Containing Four Repeated Sequences," Genetics and Molecular Biology of Industrial Microorganisms, 176-186 (1989).
Leonard Katz and Stefano Donadio, "Polyketide Synthesis: Prospects for Hybrid Antibiotics," Annu. Rev. Microbiol., 47:875-912 (1993).
Stefano Donadio, et al., "Biosynthesis of the erythromycin macrolactone and a rational approach for producing hybrid macrolides," Gene, 115:97-103 (1992).
Dougals J. MacNeil, et al., "Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase," Gene, 115:119-125 (1992).
Douglas J. MacNeil, et al., "Correlation of the Avermectin Polyketide Synthase Genes to the Avermectin Structure," Annals New York Academy of Sciences, 721:123-132 (1994).
C. Richard Hutchinson, "Drug Synthesis by Genetically Engineered Microorganisms," Bio/Technology, 12:375-380 (1994).
Omura, S., et al., Journal of Biochemistry (Tokyo), vol. 86, Isolation and properties of spiramycin 1 3-hydroxyl acylase from Streptomyces ambofaciens:, pp. 1753-1758, (1979).
Richardson, M.A. et al., Journal of Facteriology, vol. 172, "cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis", pp. 3790-3798, (1990).
Geistlch, M., et al., Molecular Microbiology, vol. 6, "Characterization of a novel regulatory gene governing the expression of polyketide synthase gene in Streptomyces ambofaciens", pp. 2019-2029, (1992).
Kirst, H.A., Progress in Medicinal Chemistry, vol. 31, "Semisynthetic derivatives of 16-membered macrolide antibiotics".
Katz, L., et al., in Genetics and Biochemistry of Antibiotic Production, Vining, L.C., et al., Eds., Butterworth-Heinemann, Pub., "Macrolides", pp. 385-420, (1995).
Li, T., et al., Chinese Journal of Biotechnology, vol. 7, "Cloning and expression of spiramycin polyketide synthase genes from S. spiramyceticus U-941", pp. 33-42, (1996).
Kuhstoss, S., et al., Gene, vol. 183, "Production of a novel polyketide through the construction of hybrid polyketide synthase", pp. 231-236, (1996).
Aigle, B., et al., Microbiology, vol. 142, "An amplifiable and deletable locus of Streptomyces ambofaciens RP181110 contains a very large gene homologous to polyketide synthase genes", pp. 2815-2824. (1996).
Maezawa, I., et al., "Biological Gycosidation of Macrolide Aglycones. II Isolation and Characterization of Desosaminyl-Platenolide I," The Journal of Antibiotics, 31:309-318 (1978).
Furumai, T., et al., "Studies on the Biosynthesis of Basic 15-Membered Macrolide Antibiotics, Platenomycins, III Production, Isolation and Structures of Platenolides I and II," The Journal of Antibiotics, 28:783-788 (1975).
Furumai, T., et al., "Studies on the Biosynthesis of Basic 16-Membered Macrolide Antibiotics, Platenomycins, II Production, Isolation and Structures of 3-O-Propionyl-5-Omycaminosyl Platenolides I and II, 9-Dehydro Demycarosyl Platenomycin and Demycarosyl Platenomycin," The Journal of Antibiotics, 28:775-782 (1975).
Furumai T., et al., "Studies on the Biosynthesis of Basic 1-Membered Macrolide Antibiotic, Platenomycins. I* Selection of and Cosynthesis by Non-platenomycin-Producing Mutants," The Journal of Antibiotics, 28:770-774 (1975).
Grafe, U., et al., Isolation and Structures of Nitrogen-Free Platenolide Glycosides 11. The 5-O-(.alpha.-Mycarosyl)-and 5-O(3'-Demethyl-.beta.-Mycarosyl)-Platenolides I and II, The Journal of Antibiotics, 33:574-578 (1980).
Grafe, U. et al., Isolation and Structures of Nitrogen-Free Platenolide Glycosides I. The 5-O-(Deoxy-3'-C-acetyl-.beta.-D-Hexopyranosyl)-Platenolides I and II, The Journal of Antibiotics, 33:566-573 (1980).
Grafe, U., et al., "The Platenolides I and II as Precursors of Turimycin", The Journal of Antibiotics, 33:663-664 (1980).
Rakhit, S., et al., "Structure Activity Relationship in Sixteen Membered Macrolide Antibiotics," The Journal of Antibiotics, 27:221-224 (1974).
Omura, S., et al., "Biosynthetic Origin of Carbons 3 and 4 of Leucomycin Aglycone", The Journal of Antibiotics, 36:611-613 (1983).
Omura, S., et al., Journal of Biochemistry (Tokyo), vol. 86, "Isolation and properties of spiramycin 1 3-hydroxl acylase from Streptomyces ambofaciens", pp. 1753-1758, 1979.
Richardson, M. A., et al., Journal of Bacteriology, vol. 172, "Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defectve in spiramycin biosynthesis", pp. 3790-3798, 1990.
Kirst, H.A., Progress in Medicinal Chemistry, vol. 31, "Semi-synthetic derivatives of 16-membered macrolide antibiotics", pp. 266-299, 1994.

Affiliated with

Also associated with

Rating

Platenolide synthase gene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Platenolide synthase gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platenolide synthase gene will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2426376