Nucleic acids encoding two human heat shock protein homologs, an

Details Nucleic acids encoding two human heat shock protein homologs, an Nucleic acids encoding two human heat shock protein homologs, an

1997-11-19

1999-08-31

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 435 701, 435 711, 435 912, 43525221, 4352523, 43525233, 4353201, 435325, 435348, 435350, 4353722, 435419, 536 231, 536 235, 536 241, 536 2431, 536 2433, 530350, C12P 2106, C12Q 168, C12N 1500, C07H 2104

Patent

active

059452870

ABSTRACT:
The invention provides two human heat shock protein homologs (HSPHH-1, HSPHH-2) and polynucleotides which identify and encode HSPHH-1 and HSPHH-2. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HSPHH-1 and HSPHH-2.

REFERENCES:
GenBank Accession No. T11789-published first Apr. 7, '96.
Hata, M., et al., "Genomic Cloning of a Human Heat Shock Protein 40 (Hsp40) Gene (HSPF1) and Its Chromosomal Localization to 19p13.2," Genomics, 38(0653):446-449 (1996) (GI 816451).
Cheret, G., et al., "DNA Sequence Analysis of the VPH1-SNF2 Region on Chromosome XV of Saccharomyces cerevisiae," Genomics, 12:1059-1064 (1996) (GI 279709).
Miron, T., et al., "A 25-kD Inhibitor of Actin Polymerization Is a Low Molecular Mass Heat Shock Protein," The Journal of Cell Biology, 114(2):255-261 (1991).
Marber, M., et al., "Overexpression of the Rat Inducible 70-kD Heat Stress Protein in a Transgenic Mouse Increases the Resistance of the Heart to Ischemic Injury," J. Clin. Invest., 95:1446-1456 (1995).
Simon, M., et al., "Heat Shock Protein 70 Overexpression Affects the Response to Ultraviolet Light in Murine Fibroblasts," J. Clin. Invest., 95:926-933 (1995).
Udono, H., and Srivastava, K., "Comparison of Tumor-Specific Immunogenicities of Stress-Induced Proteins gp96, hsp90, and hsp70.sup.1," Journal of Immunology, 152:5398-5403 (1994).
Fang, Y., et al., "Hsp90 Regulates Androgen Receptor Hormone Binding Affinity in Vivo*," The Journal of Biological Chemistry, 271(45):28697-28702 (1996).
Sargent, C., et al., Human major histocompatibility complex contains genes for the major heat shock protein HSP70, Proc. Natl. Acad. Sci. USA, 86:1968-1972 (1989).
Hendrick, J., et al., "Control of folding and membrane translocation by binding of the chaperone DnaJ to nascent polypeptides," Proc. Natl. Acad. Sci. USA, 90:10216-10220 (1993).
Hata, M., et al., (GI 1816451) GenBank Sequence Database (Accession D85429) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Cheret, G., et al., (GI 1279709) GenBank Sequence Database (Accession X89633) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.

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