Human oxalyl-coa decarboxylase

Details Human oxalyl-coa decarboxylase Human oxalyl-coa decarboxylase

1997-06-03

1999-08-31

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

495232, C12Q 100, C12N 988

Patent

active

059452730

ABSTRACT:
A human oxalyl-CoA decarboxylase polypeptide and DNA(RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.

REFERENCES:
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Chemical Abstracts 118:143063p (1993).
Quayle, J. R, et al., Methods in Enzymology 13:369-372 (1969).

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