Photocleavable steroids

Details Photocleavable steroids Photocleavable steroids

1977-04-13

1978-04-25

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26023955D, C07J 500

Patent

active

040862542

ABSTRACT:
This invention relates to novel compounds of the formula: ##STR1## wherein X is H, methoxy, bromine or chloro; R.sub.1 is hydrogen or hydroxy, acyloxy wherein acyl is 2 to 8 carbon atoms, R.sub.2 is hydrogen, hydroxy, methyl, fluoro or chloro; and R.sub.1 and R.sub.2 taken together can be ##STR2## R.sub.3 is hydrogen, methyl, chloro, or fluoro; R.sub.4 is hydrogen, chloro or fluoro; R.sub.5 is oxygen, .beta.-hydroxy or .beta.-chloro, with the proviso that when R.sub.5 is .beta.-chloro then R.sub.4 must be chloro.
The compounds have a photocleavable group (R) which is removable by irradiation. The compounds have reduced activity in the uncleaved state and provide a therapeutically active compound upon irradiation at the site of irradiation.

REFERENCES:
patent: 2183589 (1939-12-01), Reichstein et al.
patent: 2862938 (1958-12-01), Rebenstorf

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