Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1988-03-25
1989-08-22
Swisher, Nancy A. B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
A61K 3119
Patent
active
048597040
ABSTRACT:
A novel water soluble alkali metal salt of ibuprofen is prepared by reacting ibuprofen and an alkali metal bicarbonate in a aqueous medium. The salt is useful in treating pain, inflammation, and fever in mammals. It permits the preparation of a number of novel formulations which result in pharmaceutically and commercially acceptable dosage forms.
REFERENCES:
patent: 3041239 (1962-06-01), Nashed
patent: 3228831 (1966-01-01), Nicholson et al.
patent: 3385886 (1968-05-01), Nicholson et al.
patent: 3733410 (1973-05-01), Asche
patent: 3903297 (1975-09-01), Robert
patent: 3911137 (1975-10-01), Miki et al.
patent: 3927205 (1975-12-01), Ohno et al.
patent: 4031243 (1977-06-01), Aparicio et al.
patent: 4145440 (1979-03-01), Fitch et al.
patent: 4282252 (1981-08-01), Lefer
patent: 4344929 (1972-08-01), Bonsen et al.
patent: 4346108 (1982-08-01), Singer
patent: 4361580 (1982-11-01), Peck et al.
patent: 4389393 (1983-06-01), Schor et al.
patent: 4404210 (1983-09-01), Schmidt
patent: 4439450 (1984-03-01), Coleman
patent: 4447443 (1984-05-01), Goldenberg
patent: 4447451 (1984-05-01), Mueller
patent: 4536595 (1985-08-01), Gardano et al.
patent: 4545992 (1985-10-01), Kamashita
patent: 4552899 (1985-11-01), Sunshine et al.
patent: 4555524 (1985-11-01), Gruber et al.
patent: 4558051 (1985-12-01), Sunshine et al.
patent: 4569937 (1986-02-01), Baker et al.
patent: 4571400 (1986-02-01), Arnold
patent: 4587252 (1986-05-01), Arnold
patent: 4599359 (1986-07-01), Cooper
patent: 4609675 (1986-09-01), Franz
patent: 4619934 (1986-10-01), Sunshine et al.
patent: 4681897 (1987-07-01), Brand
patent: 4687662 (1987-08-01), Schobel
patent: 4689218 (1987-08-01), Gazzaniga et al.
patent: 4690823 (1987-09-01), Lohner et al.
patent: 4713249 (1987-12-01), Schroder
patent: 4717713 (1988-01-01), Zatz et al.
patent: 4726966 (1988-02-01), Kawashima et al.
patent: 4788220 (1988-11-01), Mody et al.
Moore et al., "Postextraction Pain Relief in Children: A Clinical Trial of Liquid Analgesics", International Journal of Clinical Pharmacology, Therapy and Toxicology, vol. 23, No. 11-1985, pp. 573-577.
Morrison et al., Organic Chemistry, Third Edition, 1973, pp. 579-584.
Norman et al., "A Double-Blind Comparison of a New Ibuprofen-Codeine Phosphate Combination, Codeine Phosphate, and Placebo in the Relief of Postepisiotomy Pain", Clinical Therapeutics, vol. 7, No. 5, 1985, pp. 549-554.
Martindale, The Extra Pharmacopoeia, 27th Edition, 1977, pp. 192, 193, 915-917, 931, 932, 1265-1267, 1442-1446.
Adams et al., "The Pharmacological Properties of Ibuprofen, An Anti-Inflammatory, Analgesic and Anti-Pyretic Agent", Arch. int. Pharmacodyn., 1969, vol. 178, No. 1, pp. 115-129.
Glenn et al., "In Vitro Effects of Non-Steroidal Anti-Inflammatory Drugs (NAIFD)", Proc. Soc. Erp Med., vol. 130, 1969, pp. 1327-1332.
Huskisson et al., "Ibuprofen, A Review", Practitioner, vol. 207, 1971, pp. 639-643.
Brooks et al., "Tolerance and Pharmacology of Ibuprofen", Current Therapeutic Research, vol. 15, No 4, Apr. 1973, pp. 180-190.
"Summary Basis of Approval of Nuprin", 1984, NDA 19-012, Section IV, p. 2 and Section V, pp. 3-27.
Motrin, Physician's Desk Reference, 41st Edition, 1987, pp. 2058-2060.
Sheth et al., "Measurement of Antipyretic Activity of Ibuprofen and Paracetamol in Children", J. Clin. Pharmacol., vol. 20, 1980, pp. 672-675.
Gaitonde et al., "Antipyretic Activity of Ibuprofen (Brufen)", J. Assoc. Physicians India, vol. 21, 1973, pp. 579-584.
Simila et al., "Oral Antipyretic Therapy, Evaluation of Ibuprofen", Scand J Rheumatology, vol. 5, 1976, pp. 81-83.
Phadke, et al., "Ibuprofen in Children with Infective Disorders-Antipyretic Efficacy", Br J Clin Pract, Nov.-Dec. 1985, pp. 437-440.
Amdekar et al., "Antipyretic Activity of Ibuprofen and Paracetamol in Children with Pyrexia", Brit J Clin Pract, Apr. 1985, pp. 140-143.
Kandoth, et al., "Comparative Evaluation of Antipyretic Activity of Ibuprofen and Aspirin in Children with Pyrexia of Varied Aetiology", J. Int. Med. Res., vol. 12, 1984, pp. 292-297.
Kotob, "A Comparative Study of Two Dosage Levels of Ibuprofen Syrup in Children with Pyrexia", J. Int. Med. Res., vol. 13, 1985, pp. 122-126.
Adams et al., "Some Biological Properties of 2-(4-Isobutylphenyl)-propionic Acid", J. Pharm. Sci., vol. 56, 1967, p. 1686.
Davis, "Drug Evaluation Data, Ibuprofen", Drug Intelligence and Clinical Pharamcy, vol. 9, 1979, pp. 501-503.
Adams et al., "Ibuprofen and Flurbiprofen", Clinics in Rheumatic Diseases, vol. 5, No. 2, Aug. 1979, pp. 359-379.
Greenblatt et al., "Absorption and Disposition of Ibuprofen in the Elderly", Arthritis and Rheumatism, vol. 27, No. 9, Sep. 1984, pp. 1066-1069.
Whitehall Company Product Monograph, Advil, 1984, p. 43.
Blechman et al., "Ibuprofen or Aspirin in Rheumatoid Arthritis Therapy", Journal of the American Medical Association, vol. 233, pp. 336-339.
Dornan et al., "Comparison of Ibuprofen and Acetylsalicylic Acid in the Treatment of Rheumatoid Arthritis", CMA Journal, vol. 110, Jun. 22, 1974, pp. 1370-1372.
Royer et al., "A Six-Month Double-Blind Trial of Ibuprofen and Indomethacin in Osteoarthritis", Current Therapeutic Research, vol. 17, No. 2, Mar. 1975, pp. 234-248.
Muckle, "Comparative Study of Ibuprofen and Aspirin in Soft-Tissue Injuries", Rheumatol. and Rehab., vol. 13, 1974, pp. 141-147.
Abstract of Vecchio, et al., "Efficacy of Ibuprofen in Muscle Contraction Headache", Clinical Pharmacology & Therapeutics, vol. 33, No. 2, 1983, p. 199.
Shapiro et al., "The Effect of Ibuprofen in the Treatment of Dysmenorrhea", Curr. Ther. Res., vol. 30, pp. 327-333.
Cooper et al., "Comparative Analgesic Potency of Aspirin and Ibuprofen", J Oral Surgery, vol. 35, Nov. 1977, pp. 898-903.
Bloomfield et al., "Comparative Efficacy of Ibuprofen and Aspirin in Episiotomy Pain", Clin. Pharmacol. Ther., vol. 15, 1974, pp. 565-570.
Perry et al., "Ibuprofen Overdose: The First Two Years of Over-The-Counter Sales", Human Toxocol., vol. 6, 1987, pp. 173-178.
Hall et al., "Ibuprofen Overdose: 126 Cases", Annals. of Emergency Medicine, vol. 15, Nov. 1986, pp. 1308-1313.
Bibliography (1966 to Apr. 1988), Obtained from a Search of the Medli Computer Data Base Calling for all Documents with the Word "Ibuprofen" in the Titles.
Computer Printouts Resulting from Searches of the Following Computer Data Bases for Documents Containing the Words "Ibuprofen", and any of Child, Pediatric, or Infant: Dialog, Medline, International Pharmaceutical Abstracts, Pharmaceutical News Index, and Clinical Abstracts.
Oratech Pharmaceutical Development Corporation
Swisher Nancy A. B.
LandOfFree
Water soluble ibuprofen compositions and methods of making them does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Water soluble ibuprofen compositions and methods of making them, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Water soluble ibuprofen compositions and methods of making them will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2417926