Intermediate useful for the asymmetric synthesis of duloxetine

Details Intermediate useful for the asymmetric synthesis of duloxetine Intermediate useful for the asymmetric synthesis of duloxetine

1994-07-18

1996-02-13

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D33316

Patent

active

054912431

ABSTRACT:
This invention provides a stereospecific process for the synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a key intermediate in the synthesis of duloxetine.

REFERENCES:
patent: 5023269 (1991-06-01), Robertson et al.
Deeter, et al., Tetrahedron Letters, 31(49), 7101-7104 (1990).
Wong, et al., Life Sciences, 43, 2049-2057 (1988).
Reinheimer, et al., J. Am. Chem. Soc., 83, 2873-2877 (1961).
Reinheimer, et al., J. Am. Chem. Soc., 80, 164-168 (1958).
Deeter et al., Tet. Lett., 31(49), 7101-7104, 1990.

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