Thermal measuring and testing – Calorimetry – With control of heat added to or lost from a sample container
Patent
1987-07-02
1989-08-22
Cuchlinski, Jr., William A.
Thermal measuring and testing
Calorimetry
With control of heat added to or lost from a sample container
422 51, 374 31, G01K 1700, G01N 2548
Patent
active
048590770
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention relates to a precision calorimeter and more specifically to an apparatus for determining a small amount of heat generated due to, for instance, thermal reaction of erythrocytes derived from the same origin as that of plasma with plasma which contains cells and is obtained by lightly centrifuging blood, heparin-added blood to removing only erythrocytes therefrom.
BACKGROUND OF THE INVENTION
As the inventor has already reported on Diagnosis and Treatment according to Chinese Medicine (KANPO SHINRYO), October, Showa 60 (1985), p. 57 (issued every two months), the inventor has tried to detect differences in reactivity of living bodies for the purpose of selecting herb medicines. As a result, it has been found that there is a specific relationship between thermal reactions of plasma containing cells, from which only erythrocytes are removed by a light centrifugation of human blood or heparin-added blood with erythrocytes derived from the same origin as that of plasma, sheep blood cells (heterologous erythrocyte) or PHA and diseases.
However, conventional precision calorimeters comprise a detection bath disposed in a temperature controlled bath and a thermocouple and a pipe for passing samples therethrough disposed in the detection bath, the temperature controlled bath being filled with air or water and the detection bath being filled with air. In other words, since the thermocouple is surrounded by an air layer in order to prevent corrosion thereof, there are problems such that it is difficult to control the temperature around the thermocouple and to detect the amount of heat in an accuracy sufficient to conduct the aforementioned medical inspection.
The present invention is directed to the foregoing problems and it is an object of the present invention to provide a precision calorimeter which makes it possible to stably use it for a long period of time without causing corrosion of the portion for detecting quantity of heat, to easily control the temperature within the temperature controlled bath and to detect the amount of heat in a high precision.
DISCLOSURE OF THE INVENTION
The structural characteristics of the precision calorimeter according to the present invention which accomplish the aforementioned object resides in that the calorimeter comprises a heater, an agitator and a detection bath which are disposed within a temperature controlled bath, the gaps formed therebetween being filled with a liquid and that a unit for detection is disposed in the detection bath, the gap therebetween being filled with a liquid and that the detection unit is comprised of a detecting element, a pipe for passing samples therethrough provided with a mixer and a reference heater which are arranged between metallic pieces.
BRIEF EXPLANATION OF THE DRAWINGS
FIG. 1 is a block diagram for explaining an example of the present invention;
FIG. 2 is an exploded view of the detection present invention; block;
FIG. 3 is a perspective view of an aluminum cylinder; and
FIG. 4 is a perspective view of the detection unit.
THE MOST PREFERRED EMBODIMENT FOR CARRYING OUT THE INVENTION
The precision calorimeter of the present invention is explained with reference to the accompanying drawings which show the most preferred embodiment of the present invention. As seen from FIG. 1, the precision calorimeter is constructed by the combination of a temperature controlled bath 2 and a cover 4 which also serves as a bed for placing other elements. In the temperature controlled bath 2, there are arranged a spiral heater 8 which is connected to a heat source 6 disposed outside the bath, an agitator 12 which rotates within the spiral heater 8 by means of a motor 10 placed on the cover 4 and a detection unit 14 and a proper amount of water is introduced in the temperature controlled bath.
The detection unit 14 comprises a detection block 22 which is constructed by putting, between a thermocouple 20, a reference heater 16 consisting of one or a plurality of heating elements and a pipe 18 for passing
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Nichijo Shinryo ni Yakudatsu "Kanpo Shinryo", vol. 4, No. 5, Oct. 1985, pp. 57-63.
S. Randzio et al., "A Flow Calorimeter with Active Heat Exchangers," J. Phys. E: Scientific Inst., vol. 13, pp. 1292-1296 (1980).
W. Frankvoort et al., "Design and Use of a Dynamic Controlled Adiabatic Liquid-Phase Reaction Calorimeter, " J. Phys: E: Sci. Inst. vol. 10, pp. 906-910, (1977).
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Ito Akihiro
Ito Hiroyasu
Ito Shoziro
Cuchlinski Jr. William A.
Scanlon Patrick R.
Shoziro Ito
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