Process for preparing levomepromazine hydrogen maleate

Details Process for preparing levomepromazine hydrogen maleate Process for preparing levomepromazine hydrogen maleate

1987-06-24

1989-01-17

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27928

Patent

active

047988959

ABSTRACT:
Levomepromazine hydrogen maleate is prepared by resolving (.+-.)-10-(3-dimethylamino-2-methylpropyl)-2-methoxyphenothiazine with (-)-di(p-toluoyl)-L-tartaric acid to produce the neutral salt of the dextrorotatory base and then adding maleic acid to the mother liquors to precipitate the levomepromazine hydrogen maleate.

REFERENCES:
Gyogyszer, Chemical Abstracts, vol. 63 (1965) 13279b.
Pataki et al., Chemical Abstracts, vol. 72 (1970) 132,762w.
Wrotek et al., Chemical Abstracts, vol. 80 (1974) 3541q.
Jakfalvi et al., Chemical Abstracts, vol. 102 (1985) 203977w.
Jacques et al., Enantiomers, Racemates and Resolutions, Wiley-Interscience, New York (1981) pp. 72, 73 & 256.

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