Synergistin derivatives and pharmaceutical compositions which co

Details Synergistin derivatives and pharmaceutical compositions which co Synergistin derivatives and pharmaceutical compositions which co

1987-05-21

1989-01-17

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514 11, 530317, 540455, A61K 3702, A61K 3142, C07K 512, C07D49814

Patent

active

047988274

ABSTRACT:
The invention provides new synergistin derivatives of formula ##STR1## in which Y is hydrogen or dimethylamino and R is a 3- or 4-quinuclidinyl radical, the isomers thereof and their mixtures, and their salts, also the preparation thereof. These compounds may be made by reaction of the corresponding 5-methylene compounds with the appropriate mercaptoquinuclidine. The products of formula (I), optionally combined with pristinamycin II.sub.A or a derivative of pristinamycin II.sub.B of the formula ##STR2## are useful as antimicrobials.

REFERENCES:
patent: 4617290 (1986-10-01), Corbet et al.
patent: 4617377 (1986-10-01), Corbet et al.
patent: 4618599 (1986-10-01), Corbet et al.
patent: 4668669 (1987-05-01), Barriere et al.
Chemical Abstracts, vol. 103, (1985), Item 160861e, Abstracting French Demande FR 2,549,065, Jan. 18, 1985.
Chemical Abstracts, vol. 103, (1985), Item 160862f, Abstracting French Demande FR 2,549,063.

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