Beta-lactams and their production

Details Beta-lactams and their production Beta-lactams and their production

1992-11-10

1994-05-10

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540350, C07D48704

Patent

active

053108973

ABSTRACT:
A beta-lactam compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, the same or different, each a hydrogen atom or a lower alkyl group, R.sub.3.sup.0 is a hydroen atom or a lower alkyl group having a beta-configuration, R.sub.4 is a carboxyl-protecting group, X is a hydrogen atom or a protected hydroxyl group and COZ is a protected thiolcarboxyl group, which is useful as a valuable intermediate in the stereospecific production of 1-alkylcarbapenem compounds.

REFERENCES:
patent: 3950357 (1976-04-01), Kahan et al.
patent: 4350631 (1982-09-01), Christensen et al.
Journal of American Chemical Society, 100, p. 313 (1978).
Heterocycles, vol. 21, No. 1 (1984) pp. 29-40.
von Riccardo Scartazzini et al., (1974), Helvetica Chimica Acta (vol. 2) Fasc. 7, 1919-1924.
von Riccardo Scartazzini et al., (1973), Helvetica Chimica Acta (vol. 58, Fasc. 8), 2437-2441 (1975).
Schmitt et al. (1980) J. Org. Chem., 45 (6) 1142-1145.
Smith et al. (1981) Journal of Pharmaceutical Sciences 70 (3) 272-276.
Farina et al. (1989) J. Org. Chem. 54:4962-4966.
Sowinn et al. (1988) J. Org. Chem., 53:4154-4156.
Heterocycles, vol. 21, No. 1 (1984), pp. 29-40.
Recent Advances in the Chemistry of Beta-Lactam Antibiotics, 3rd Edition, pp. 86-99 (1985).
Tetrahydron Letters, vol. 30, pp. 1345-1348 (1989).
Hine, Physical Organic Chemistry pp. 242-243 (1962).
Hutanaka, Tet Letters, 22 3883 (1981).
Hutanaka, Tet Letter 22, 2387 (1984).

Affiliated with

Also associated with

Rating

Beta-lactams and their production does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Beta-lactams and their production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Beta-lactams and their production will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2413205