Receptors: their identification, characterization, preparation a

Details Receptors: their identification, characterization, preparation a Receptors: their identification, characterization, preparation a

1993-06-08

1994-05-10

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound other than saccharide containing a...

435 697, 4352523, 4353201, 436501, 536 234, C12N 1562, C12N 1563

Patent

active

053106628

ABSTRACT:
Disclosed are novel hormone and hormone-like receptors Wherein the trans-activation transcription domain(s) is modified in terms of position and/or copy number or otherwise versus parent receptor, such novel receptors having increased trans-activation transcription activation properties surprisingly superior to the parent receptor. Also disclosed are the recombinant methods and means for preparing such receptors and assays based upon the use of such receptors for screening and identifying putative materials that can affect such receptors and/or for the expression via induced transcription of a reporter or other desired, preferably heterologous gene or DNA product.

REFERENCES:
patent: 5171671 (1992-12-01), Evans et al.
Cell 46:645-652 (Aug. 29, 1986) Giguere et al. Functional Domains of the Human Glucocorticoid Receptor.
Science 240:889-895 (May 13, 1988) Evans The Steroid and Thyroid Hormone Receptor Superfamily.
Cell 49:39-46 (Apr. 10, 1987) Hollenberg et al. Colocalization of DNA-Binding and Transcriptional Activation Functions in the Human Glucocorticoid Receptor.

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