Palladium catalyzed vinylic substitution reactions with 2-substi

Details Palladium catalyzed vinylic substitution reactions with 2-substi Palladium catalyzed vinylic substitution reactions with 2-substi

1995-05-26

1997-07-08

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546300, 546303, C07D21363, C07D21366, C07D21365

Patent

active

056462867

ABSTRACT:
This invention involves a coupling reaction involving an organo-metallic catalyst, preferably a palladium catalyst involving reacting 2-halo-3-hydroxy-6-hydroxymethylpyridine, acrylic acid or its alkali metal salt and benzyl or a phenylalkyl derivative in presence of a dipolar aprotic solvent producing none other than the expected 2-propenoate-3-benzyl or phenylalkylether-6-hydroxymethyl-pyridine product. Said products are converted into medicaments useful for treating psoriasis.

REFERENCES:
Daines et al., Journal of Medicinal Chemistry, vol. 36, No. 18, pp. 2703-2705, Sep. 1993.
Daines et al., Journal of Medicinal Chemistry, vol. 37, No. 20, pp. 3327-3336, Apr. 1994.
Chambers et al., Chemical Abstracts, vol. 119, No. 13 Abst. No. 139, 113h, Sep. 27, 1993.
Daines et al., Chemical Abstracts, vol. 120, No.No. 19, Abst. No. 244, 688t, May 1994

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