Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1993-10-14
1997-07-08
Killos, Paul J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
A01N 3702
Patent
active
056461852
ABSTRACT:
Disclosed is a method of treating a solid tumor, where the tumor contains regions of hypoxic cells, either because of poor vascularization in the tumor or because of vasoconstrictive or vaso-occlusive measures brought to bear on the tumor. The method includes administering to a subject, a compound effective to activate protein kinase C activity in the cells of the tumor, via a route effective to direct the compound to such regions of hypoxia in the tumor. Preferred compounds include phorbol esters, diacylglycerols, and thapsigargin. Also disclosed is a vaso-occlusive composition containing a protein kinase C activator, for use in the treatment method.
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Giaccia Amato J.
Koong Albert C.
Dehlinger Peter J.
Evans Susan T.
Killos Paul J.
Stratford Carol A.
The Board of Trustees of the Leland Stanford Junior University
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