Process for the production of gelatinase catalytic domain protei

Details Process for the production of gelatinase catalytic domain protei Process for the production of gelatinase catalytic domain protei

1994-09-08

1997-07-08

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, 4353201, 536 232, C12N 1557, C12N 1563, C12P 2100

Patent

active

056460279

ABSTRACT:
A process for the production of the catalytic domain, without propeptide, C-terminal domain, and the fibronectin-like insert, of human gelatinases is described which comprises culturing transformed E. coli host cells carrying a synthetic DNA sequence encoding the catalytic domain as well as a method for screening for inhibitors of a gelatinase; a method for determining the 3-dimensional structure of the catalytic domain of a gelatinase; and pharmaceutical compositions of human gelatinase catalytic domain protein which are useful in treating herniated vertebral discs, dermal ulcers, modifying scar tissue formation, and joint diseases.

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