Substituted diaminophthalimides and analogues

Details Substituted diaminophthalimides and analogues Substituted diaminophthalimides and analogues

1994-12-21

1996-02-13

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514250, 514256, 514275, 514333, 514397, 514414, 514416, 514417, 546256, 5483121, 548467, 548472, 548473, 548474, 548475, 548476, 544212, 544296, 544345, A61K 3140, A61K 31505, C07D20948, C07D24138

Patent

active

054911443

ABSTRACT:
Compounds of formula I ##STR1## wherein Ar.sub.1, Ar.sub.2, A.sub.1, A.sub.2, R and X are as defined in the description, exhibit valuable pharmaceutical properties and are effective especially against diseases responsive to the inhibition of protein kinases, for example tumors. They are prepared in a manner known per se.

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Matlin et al, "Reactions of 1,2-bis(trimethylsiloxy)cyclohexene with amines," Journal of Chemical Research (M), 1920-1943, (1990).
Wohrle et al, Synthesis, Feb. 1993, pp. 194-196. "A Simple Synthesis of 4,5-Dicyanobenzenes and 2,3,9,10,16,17,23,24-Octasubstituted Phthalocycanines".

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