Process for the synthesis of 1.alpha.,23(S),25-trihydroxycholeca

Details Process for the synthesis of 1.alpha.,23(S),25-trihydroxycholeca Process for the synthesis of 1.alpha.,23(S),25-trihydroxycholeca

1983-12-27

1986-06-10

Love, Ethel G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2603972, 549374, 549554, 556449, 568819, C07D31906, C07D30312, C07F 704, C07C 3522

Patent

active

045944326

ABSTRACT:
The invention is directed to a process and intermediates for the preparation of 1.alpha.,23(S),25-trihydroxycholecalciferol and 1.alpha.,23(R),25-trihydroxycholecalciferol. The end-products, 1.alpha.,23(S),25-trihydroxycholecalciferol and 1.alpha.,23(R),25-trihydroxycholecalciferol, are useful for the treatment of disease states which are characterized by insufficient amounts of 1,25 dihydroxycholecalciferol.

REFERENCES:
patent: 4360472 (1982-11-01), DeLuca et al.
patent: 4367177 (1983-01-01), DeLuca et al.
Partridge et al., Vitamin D, Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism, Feb. 1982, pp. 1073-1078.
Baggiolini et al., Vitamin D, Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism, Feb. 1982, pp. 1089-1094.
Ikekawa et al., J.C.S. Chem. Comm. (1981), pp. 1157-1159.
Napoli et al., Calcif. Tissue Int. 34, (Suppl. 1) S56, p. 1137, (1982).

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