Method for preparing 3-(methylmercaptol) propylaminobleomycin

Details Method for preparing 3-(methylmercaptol) propylaminobleomycin Method for preparing 3-(methylmercaptol) propylaminobleomycin

1973-11-02

1976-06-01

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424180, C07H 706

Patent

active

039608344

ABSTRACT:
By thermal decomposition of 3-(S,S-dimethylmercapto)propylaminobleomycin, there is easily obtained 3-(methylmercapto)propylaminobleomycin which is a useful antibiotic substance having an extremely high antimicrobial activity and a carcinostartic activity with low toxicity.

REFERENCES:
patent: 3846400 (1974-11-01), Umezawa et al.
Houben-Weyl, Methoden der Organischen Chemie, Vol. IX, 1955, pp. 189-190.
Takita et al., Chemistry of Bleomycin, V, J. of Antibiotics, Vol. 24, No. II, pp. 795-796 1971.

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