Photochemistry for the preparation of biologic grafts--allograft

Details Photochemistry for the preparation of biologic grafts--allograft Photochemistry for the preparation of biologic grafts--allograft

1996-09-04

1998-10-20

Isabella, David

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

A61F 202

Patent

active

058240802

ABSTRACT:
Photodynamic therapy (PDT), a technique to produce cytotoxic free radicals, was used to prepare arterial allografts. After impregnation with the photo-sensitizer chloroaluminum sulfonated phthalocyanine, aortas of ACI rats were PDT-treated and transplanted in Lewis rats. PDT grafts were completely reendothelialized by 4 weeks.

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Grant et al., "Photodynamic therapy of normal rat arteries after photosensitisation using disulphonated aluminum phthalocynanine and 5-aminolaevulinic acid", Br. J. Cancer 70:72-78, (1994).
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LaMuraglia et al., "Cloroaluminum Sulfonated Phthalocyanine Partitioning in Normal and Intimal Hyperplastic Artery in the Rat", Amer. J. of Pathology, 142:1898-1900, (1993).
LaMuraglia et al., "Photodynamic therapy inhibition of experimental intimal hyperplasia: Acute chronic effects", J. of Vascular Surgery, 19:322-331, (Feb. 1994).
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Copy of PCT Search Report for PCT/US96/15404.

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