Tetrazole derivatives, anti-ulcer composition containing the sam

Details Tetrazole derivatives, anti-ulcer composition containing the sam Tetrazole derivatives, anti-ulcer composition containing the sam

1984-05-11

1987-05-05

Rothman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514228, 514255, 514326, 514340, 514374, 514381, 546210, 546276, 544132, 544366, 548215, 548251, C07D25704, C07D41306, C07D41312, A61K 31535

Patent

active

046633235

ABSTRACT:
Tetrazole derivatives of the formula: ##STR1## wherein R.sup.1 is an optional defined substituent; A is sulfur or a lower alkylene-thio, l is 0 or 1; B is a lower alkylene; R.sup.2 is hydroxy, a lower alkoxy, or a group: ##STR2## wherein R.sup.3 and R.sup.4 are optional defined substituents, or the R.sup.3 and R.sup.4 may combine together with the nitrogen atom to which they are joined to form a defined heterocyclic group, and a pharmaceutically acceptable salt thereof, which have prophylactic or therapeutic activities against peptic and/or duodenal ulcers and also anti-inflammatory activity and are useful as an anti-ulcer or anti-inflammatory drug; processes for the preparation of the tetrazole derivatives; and pharmaceutical composition containing said tetrazole derivatives.

REFERENCES:
patent: 4540703 (1985-09-01), Uchida et al.
Uchida et al., Chem. Abstracts, vol. 96(7), abst. No. 96:52,311d, Feb. 15, 1982.
Chem. Abstracts, vol. 96, (19), abst. No. 96:162, 707v, May 10, 1982.
Chem. Abstracts, vol. 99, (8), abst. No. 99:58894e, Aug. 22, 1983.

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