Vaccines for gram-negative bacteria

Details Vaccines for gram-negative bacteria Vaccines for gram-negative bacteria

1983-03-14

1987-05-05

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

424 92, 424 85, 424 88, A61K 3940, A61K 39104, A61K 3902

Patent

active

046631607

ABSTRACT:
An immunizing composition is disclosed and comprises a detoxified polysaccharide from a gram-negative bacterium covalently coupled to a detoxified protein from said gram-negative bacterium by means of a 4-12 carbon moiety. To prepare the above immunizing agent, the lipid A portion of lipopolysaccharide from a gram-negative bacterium is separated to give a detoxified polysaccharide. Reactive aldehyde groups are generated on the detoxified polysaccharide by selective oxidation. The detoxified polysaccharide is then covalently coupled to a detoxified protein from said gram-negative bacterium by means of a 4-12 carbon moiety having functionalities reactive to the aldehyde groups on the detoxified polysaccharide and to the carboxylic groups on the detoxified protein.

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patent: 4372883 (1983-02-01), Matuhashi et al.
Jennings, H. et al., J. Immunology, vol. 127, pp. 1211-1218, 1981.
Schneerson, R. et al., J. Experimental Medicine, vol. 132, pp. 361-376, 1980.
Chemical Abstracts, vol. 94, Abstract No. 145220x, 1981.

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