Preparation of addition salts of cysteamine with acids

Details Preparation of addition salts of cysteamine with acids Preparation of addition salts of cysteamine with acids

1990-01-30

1991-05-21

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

548146, 548147, 564 1, 564462, 564500, C07C32325

Patent

active

050177257

ABSTRACT:
Addition salts of cysteamine with acids are prepared by reacting aziridine with an organic sulfur compound of oxidation state -2 and with a ketone and then subjecting the thiazolidine formed as an intermediate to acid hydrolysis, by a process in which aziridine and the ketone are reacted with ammonium hydrogen sulfide or with a metal hydrogen sulfide with the addition of a moderately strong or strong acid at from -10.degree. to +100.degree. C. and a pH which is greater than or equal to 8.5 is maintained.

REFERENCES:
patent: 3574698 (1971-04-01), Brois et al.
patent: 4374247 (1983-02-01), Osawa et al.
patent: 4507500 (1985-03-01), Nakayama et al.
patent: 4584407 (1986-04-01), Hollowood
Chemical Abstracts, Band 79, Nr. 19, Nov. 12, 1973, Seite 354, Nr. 125805d, Columbus, Ohio.
Ann. Chem., vol. 566, pp. 210 et seq., 1950.

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