Use of diphenylbutyl-piperazinecarboxamides in the treatment of

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514811, 514813, A61K 31495

Patent

active

056188170

ABSTRACT:
The present invention relates to the relief or prevention of withdrawal syndrome resulting from addiction to non-opiate type drugs of abuse and/or the suppression of dependence on non-opiate type drugs of abuse by administering to a person in need thereof, an effective amount of certain diphenylbutyl-piperazine-carboxamides including 4-[4,4-bis(4-fluorophenyl)butyl]-N-ethyl-1-piperazine-carboxamide which is known as amperozide.

REFERENCES:
patent: 4308387 (1981-12-01), Bjork et al.
patent: 4385057 (1983-05-01), Bjork et al.
patent: 4447433 (1984-05-01), Bjork et al.
patent: 5434156 (1995-07-01), Bjork et al.
Myers et al., Pharmacology Biochemistry & Behavior, vol. 40, pp. 923-928 (1986).
The Merck Index, Eleventh Edition, pp. 655 & 1597, 1989.
Naranjo, et al., Clin. Pharmacol. Ther., vol. 47, pp. 490-498 (1985).
Naranjo et al., Clin. Pharmacol. Ther., vol. 35, No. 3, pp. 374-380 (1984).
"Reduction in Alcohol Intake in Humans as a Function of Treatment with Zimeldine: Implications for Treatment", Naranjo et al. eds., Elsevier Science Publishers B.V. (Biomed. Div.), Research Advances in New Psychopharmacological Treatments for Alcoholism (1989).
Filion et al., Alcohol, vol. 5, pp. 355-358, 1988.
Gill et al., Alcohol, vol. 5, pp. 349-354, 1988.
Murphy et al., Alcohol, vol. 5, pp. 283-286 1988.
Hyttel, Biochemical Pharmacology, vol. 27, pp. 1063-1068, 1978.
Svartengren et al., Pharmacology & Toxicology, Supplement 1, pp. 8-11, 1990.
Eriksson, Life Science, vol. 47, pp. 2111-2117, 1990.
Chiara, et al., Proc. Natl. Acad. Sic., vol. 85, pp. 5274-5278, 1988.
Wazniak, et al., Pharmacology and Biochemistry, "Recent Advances in Pharmacological Research on Alcohol", III, pp. 235-272 (1987).
Clarke, et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 246, No. 2, pp. 701-707, 1988.
Grenhoff, et al., British Journal of Addiction, vol. 84, pp. 477-492 (1988).
Weiss, et al., Annals New York Academy of Sciences, "Neurochemical Correlates of Cocaine and Ethanol Self-Administration", pp. 220-241 (1991).
Myers, et al., Pharmacology Biochemistry and Behavior, vol. 43, pp. 661-667, 1992.
Myers et al., Alcohol, vol. 10, pp. 117-125, 1993.
Myers et al., Pharmacology Biochemistry and Behavior, vol. 45, pp. 741-747, 1993.
McMillen, et al., Pharmacology Biochemistry and Behavior, vol. 46, pp. 125-129, 1993.
Multiple Authors, AMA Drug Evaluations Annual, pp. 319-320 & 326-327, 1994.
Rockman, et al., 1979, Archives of International Pharmacodynamics, 241:245-449.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of diphenylbutyl-piperazinecarboxamides in the treatment of does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of diphenylbutyl-piperazinecarboxamides in the treatment of , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of diphenylbutyl-piperazinecarboxamides in the treatment of will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2397892

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.