Production of a contractile smooth muscle

Details Production of a contractile smooth muscle Production of a contractile smooth muscle

1994-12-30

1997-04-08

Naff, David M.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435371, 435373, 435378, 435379, 435395, 424422, C12N 500, C12N 508, A61F 208

Patent

active

056187181

ABSTRACT:
A contractile smooth muscle cell construct and a method for preparing the smooth muscle cell construct are described. The smooth muscle cell construct is comprised of (i) smooth muscle cells that have been cultured in vitro under conditions to allow the formation of a sheet of smooth muscle cells and (ii) an endogenous fibrous matrix formed by the smooth muscle cells, wherein the smooth muscle cell construct retains the ability to contract in response to vasoactive agonists. The smooth muscle cell construct may be prepared in planar or tubular form and can be used to study or evaluate the contractile responses of smooth muscle cells.

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