Phenyl substituted dipeptide amides

Details Phenyl substituted dipeptide amides Phenyl substituted dipeptide amides

1986-07-14

1989-04-18

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514464, 549441, 564157, A61K 3134, C07D31754, C07D31758, C07K 506

Patent

active

048227757

ABSTRACT:
The invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is hydrogen, lower alkyl, hydroxy, --OCO.sub.2 lower alkyl, lower alkoxy, --O(CH.sub.2).sub.n -phenyl with the phenyl optionally substituted by halogen, --NO.sub.2, --CN, --NH.sub.2 or lower alkyl wherein n is 1 to 4; R.sup.2 and R.sup.3 represent lower alkyl, halogen, or lower alkoxy, or either one of R.sup.2 or R.sup.3 is hydrogen and the other is lower alkyl, lower alkoxy or halogen; R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.9 may be the same or different and represent hydrogen or lower alkyl; R.sup.10 is selected from the group consisting of

REFERENCES:
patent: 4127535 (1978-11-01), Coy et al.
patent: 4261888 (1981-04-01), Bauer et al.
patent: 4273704 (1981-06-01), Mazur
patent: 4316892 (1982-02-01), Jones
patent: 4405607 (1983-09-01), Cardinaux et al.
patent: 4407746 (1983-10-01), Mazur et al.
patent: 4450155 (1984-05-01), Morgan
patent: 4454120 (1984-06-01), Morgan
patent: 4533655 (1985-08-01), Morgan
patent: 4599325 (1986-07-01), Hansen et al.
Kiso et al., Synthesis and Activity of Short Chain Enkephalin-Like Peptides Peptide Chemistry 1981, T. Shiori (Ed), Protein Res. Foundation, Osaka (1982).
Vavarek et al., Peptides, vol. 2 pp. 303-308 (1981).

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