Preparation of crystal form II of clarithromycin

Details Preparation of crystal form II of clarithromycin Preparation of crystal form II of clarithromycin

1996-07-29

1998-12-01

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 72, 536 75, 536124, C07G 300, C07H 1500, C07H 1708, C07H 100

Patent

active

058441050

ABSTRACT:
The present invention provides a process for the preparation of 6-O-methylerythromycin A Form II comprising converting erythromycin A to 6-O-methylerythromycin A and treating the 6-O-methylerythromycin A with a number of common organic solvents or mixtures of common organic solvents.

REFERENCES:
patent: 4331803 (1982-05-01), Watanabe et al.
patent: 4990602 (1991-02-01), Morimoto et al.
Quantitative Structure-Activity Relationships In Drug Design, vol. 291 (1989), pp. 325-328, Kim et al., "Conformational Study of Erythromycin Analoques".
Acta Crystallographica, vol. c49, No. 5 (May 1993), pp. 1227-1230, Iwasaki et al., "Structure of 6-0-Methylerythromycin A (Clarithromycin)".

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