Dynorphin analogs specific for kappa opioid receptors

Details Dynorphin analogs specific for kappa opioid receptors Dynorphin analogs specific for kappa opioid receptors

1989-07-06

1991-05-21

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

530302, 530317, 514809, C07K 712, C07K 706

Patent

active

050176897

ABSTRACT:
Cyclic disulfide and linear dynorphin Dyn A.sub.1-11 and dynorphin Dyn A.sub.1-13 analogs which are highly specific for .kappa. opioid receptors. These analogs are useful in pharmaceutical compositions and for the analysis of opioid receptor/ligand interactions.

REFERENCES:
patent: 4148786 (1979-04-01), Sarantakis
patent: 4518711 (1985-05-01), Hruby et al.
patent: 4684620 (1987-08-01), Hruby et al.
Civelli et al., Proc. Natl. Acad. Sci., U.S.A., vol. 82, 1985, pp. 4291-4295.

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