Cells expressing IL-10 receptor and the CRFB4 gene product, an I

Details Cells expressing IL-10 receptor and the CRFB4 gene product, an I Cells expressing IL-10 receptor and the CRFB4 gene product, an I

1996-07-17

1998-12-01

Fitzgerald, David L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435325, 4353201, 435 721, 536 235, C12N 1512, C07K 14715, G01N 3353

Patent

active

058436979

ABSTRACT:
The present invention relates to the identification of intracellular signal transduction function for a putative cytokine receptor subunit. In particular, the invention relates to the identification of the signal transduction protein for the interleukin (IL)-10 receptor. Accordingly, the present invention relates to preparing recombinant cells that express the IL-10 receptor and the newly identified IL-10 signal transduction protein, e.g., for use in screening libraries of compounds for IL-10 agonists and antagonists; to restoring IL-10 function to cells in vivo, e.g., via gene therapy; and in addition to chimeric proteins comprising this signal transduction protein to agonize IL-10 activity. In specific examples, cells transfected with both the first chain of the IL-10R and the presently identified second chain, termed herein CRFB4, were able to transduce a signal in response to contact with IL-10.

REFERENCES:
Soh, J., et al. (1994) J. Biol. Chem. 269: 18102-10.
Cook, J. R., et al. (1996) J. Biol. Chem. 271: 13448-53.
Lutfalla, G., et al. (1993) Genomics 16: 366-73.
Ho, A. S.-Y., et al. (1994) Ther. Immunol. 1: 173-85.
Liu, Y., et al. (1997) J. Immunol. 158: 604-13.
Pestka, S. (1997) Semin. Oncol. 24 (Suppl. 9): S9-18-20.

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