Isolated, tyrosinase derived peptides and uses thereof

Details Isolated, tyrosinase derived peptides and uses thereof Isolated, tyrosinase derived peptides and uses thereof

1995-10-19

1998-12-01

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4241931, 530328, G01N 3353, A61K 39385, A61K 3804

Patent

active

058436871

ABSTRACT:
The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.

REFERENCES:
patent: 4898814 (1990-02-01), Kwon
van der Bruggen et al., A gene encoding an antigen recognized by cytolytic T lymphocytes, on a human melanoma, Sci. 254: 1643-1647, see Abstracat, p. 1643, col. 1, third sentence, second paragraph, Dec. 1991.
Ruppert et al., Multiple transcripts of the mouse tyrosinase gene are generated by alternative, splicing, The EMBO J. vol. 7, No. 9, pp. 2715-2722, p. 2715, col. 1, lines 5-7, Jun. 1988.
Traversari, et al., Transfection and expression of a gene coding for a human melanoma antigen recognized by autologous cytolyic T lymphocytes, Immunogenetics 35: 145-152, Abstract, first sentence, p. 146, col. 2, "CTL clones", p. 147, col. 1, Sc, 1992.
Brichard, et al, "The Tyrosinase Gene Codes for an Antigen-Recognized by Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas", J. Exp. Med. 178: 489-495 (1993).
Coulie, et al, "Genes Coding For Tumor Antigens Recognized by Human Cytolytic T Lymphocytes", J. Immunotherapy 14: 104-109 (1993).
Slingluff, et al, "Recognition of Human Melanoma Cells by HLA-A2.1 Restricted Cytotoxic T Lymphocytes As Mediated By At Least Six Shared Peptide Epitopes", J. Immunol. 150(7): 2955-2963 (Apr. 1, 1993).
Barinaga "Getting Some `Backbone`: How MHC Binds Peptides" Science 257: 880-881 (August 14, 1992).
Falk, et al, "Allele Specific Motifs revealed by sequencing of self-peptides eluted from MHC molecules", Nature 351: 290-296 (May 23, 1991).
Wolfel, et al, "Lysis of Human Melanoma Cells by Autologous Cytolytic T Cells Clones", J. Exp. Med. 170: 797-810 (Sep. 1989).

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