Human SQM1 protein homolog

Details Human SQM1 protein homolog Human SQM1 protein homolog

1996-11-26

1998-12-01

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435912, 436 94, 536 221, 536 231, 536 243, 536 2431, 536 2432, 536 2433, 536 245, C12Q 168, C12P 1934, C07H 2102, C07H 2104

Patent

active

058436685

ABSTRACT:
The present invention provides a polynucleotide which identifies and encodes a novel human SQM2. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding human SQM2. The invention also provides for the use of purified SQM2 and its agonists in the production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of SQM2. Additionally, the invention provides for the use of SQM2 antagonists and inhibitors, including antisense molecules to SQM2 polynucleotides (i.e., gene sequences) in pharmaceutical compositions for the treatment of diseases associated with the expression of SQM2. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts and/or genomic DNA encoding SQM2 and anti-human SQM2 antibodies which specifically bind to SQM2.

REFERENCES:
Boehim, Klaus, et al., "SQM1 Antibody Defines a Surface Membrane Antigen in Squamous Carcinoma of the Head and Neck," J. Cancer:36, 1985, pp. 137-142.
Sambrook et al, "Molecular Cloning: A Laboratory Manual", Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. 9.31, 17.2, 1989.
Nicolson, G., "Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites," Cancer and Metastasis Reviews, 7:143-188 (1988).
Edelman, G., "Cell Adhesion Molecules in the Regulation of Animal Form and Tissue Pattern," Ann. Rev. Cell Biol., 2:81-116 (1986).
Stoolman, L., "Adhesion Molecules Controlling Lymphocyte Migration," Cell, 56:907-910 (1989).
Hynes, R., "Integrins: A Family of Cell Surface Receptors," Cell, 48:549-554 (1987).
Wong, Y., et al., "cDNA Cloning of a Novel Cell Adhesion Protein Expressed in Human Squamous Carcinoma Cells," Biochemical and Biophysical Research Communications, 166(2) :984-992 (1990) (GI 180233).
Walker, J., et al., "Sequences of 20 Subunits of NADH: Ubiquinone Oxidoreductase from Bovine Heart Mitochondria," J. Mol. Biol., 226:1051-1072 (1992) (GI 244).
Bernal, S., et al., "Congruence of SQM1 Protein Expression with Methotrexate Sensitivity and Transport," Cancer Investigation, 13 (1) 23-30 (1995).
Towler, D., et al., "Myristoyl CoA:Protein N-Myristoyltransferase Activities from Rat Liver and Yeast Possess Overlapping Yet Distinct Peptide Substrate Specificites," The Journal of Biological Chemistry, 263(4) :1784-1790 (1988).
Kulaylat, M., et al., "Squamoud Cell Carcinoma Complicating Idiopathic Inflammatory Bowel Disease," Journal of Surgical Oncology, 59:48-55 (1995).
Vraux, H., et al., "Primary squamous-cell carcinoma of the colon: a case report," Acta Chir. Belg., 94:318-320 (1994).
Rosado-de-Christenson, M., et al., "From the Archives of the AFIP," Radiographics, 14(2) :429-446 (1994).
Keita, O., et al., "Primary Bronchogenic Squamous Cell Carcinoma in Children: Report of a Case and Review of the Literature," Medical and Pediatric Oncology, 24:50-52 (1995).
Stamenkovic, I., et al., "A Lymphocyte Molecule Implicated in Lymph Node Homing is a Member of the Cartilage Link Protein Family," Cell, 56:1057-1062 (1989).

Affiliated with

Also associated with

Rating

Human SQM1 protein homolog does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human SQM1 protein homolog, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human SQM1 protein homolog will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2394608