Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-10-31
1998-12-01
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435195, 4352523, 4353201, 536 232, 536 2431, C12Q 168, C12P 1934, C12N 914, C07H 2104
Patent
active
058436650
ABSTRACT:
The present invention provides a human pyrophosphatase (HPYP) and polynucleotides which identify and encode HPYP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPYP and a method for producing HPYP. The invention also provides for use of HPYP and agonists, antibodies, or antagonists specifically binding HPYP, in the prevention and treatment of cancer and inflammatory diseases. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPYP for the treatment of diseases associated with the expression of HPYP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPYP.
REFERENCES:
Yang, Z., et al., "Inorganic Pyrophosphatase from Bovine Retinal Rod Outer Segments" J. Biol. Chem., 267:24634-40 (1992).
Yang. Z., et al., "Molecular Cloning and Functional Expression of cDNA Encoding a Mammalian Inorganic Pyrophosphatase" J. Biol. Chem., 267:24641-47 (1992).
Lacroix, J., et al., (GI 727225), GenBank Sequence Database (Accession 727225), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Kolakowski, L.F., et al., "Cloning, molecular characterization and chromosome localization of the inorganic pyrophosphatase (PPA) gene from S. cerevisiae" Nuc. Acids Re., 16:10441-52 (1988).
Hawkins Phillip R.
Hillman Jennifer L.
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Prouty Rebecca E.
Slobodyansky Elizabeth
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