Methods of stimulating hematopoietic cells with flt3-ligand

Details Methods of stimulating hematopoietic cells with flt3-ligand Methods of stimulating hematopoietic cells with flt3-ligand

1997-12-18

1998-12-01

Feisee, Lila

Drug, bio-affecting and body treating compositions

Lymphokine

435 2, 435375, 435378, 530351, 530399, A61K 3819, C12N 500, C12N 1519

Patent

active

058434232

ABSTRACT:
Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Flt3-L finds use in treating patients with anemia, AIDS and various cancers.

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