Use of carbazones as novel active ingredients in medicaments

Details Use of carbazones as novel active ingredients in medicaments Use of carbazones as novel active ingredients in medicaments

1991-11-20

1993-01-05

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31425

Patent

active

051770911

ABSTRACT:
Compounds of formula I ##STR1## wherein X and Y are each independently of the other thio or sulfynyl, R.sub.1 is lower alk-2-en-1-yl, lower alk-3-en-2-yl, lower alk-2--yn-1-yl, or lower alkyl that is substituted in the 2,3-position by radicals that can be eliminated to form a double bond, R.sub.2 is hydrogen and R.sub.3 is unsubstituted methyl or methyl substituted by a radical that can be eliminated together with hydrogen Rhd 2 to form a double bond, or R.sub.2 and R.sub.3 are each hydrogen or lower alkyl or together are methylene, R.sub.4 is free or protected hydroxy, or hydrogen, and R.sub.5 is hydrogen, lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or lower alkyl that is substituted in the 2,3-position by radicals that can be eliminated to form a double bond, and their pharmaceutically acceptable salts may be used in a novel manner for the treatment of disorders of the rheumatoid type.

REFERENCES:
patent: 3699116 (1972-10-01), Meisels et al.
patent: 4489069 (1984-12-01), Storni
patent: 4582841 (1986-04-01), Storni
patent: 4697020 (1987-09-01), Storni
European Journal of Cancer, vol. 15, No. 5, 755-762 (May 1979) Jordan et al., "The Mode of Action of the Antitumour Agent GP4989 in the Pat."
Proc. Int. Cong. Chemother, vol. 16, 257/66-257/70 (1983), Schieweck et al., "CGP 19984A:Antitumour Activity in Vivo and in Vitro".
Merck Manual of Diagnosis and Therapy 15th Ed. (1987) pp. 1221-1228 and pp. 1239-1246.
Abstract of DE 2,632,747 (Feb. 1977).
Abstract of DE 2,632,746 (Feb. 1977).

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