Antidepressant 2-(4,5-dihydro-1H-imidazolyl)-dihydro-1H-indoles,

Details Antidepressant 2-(4,5-dihydro-1H-imidazolyl)-dihydro-1H-indoles, Antidepressant 2-(4,5-dihydro-1H-imidazolyl)-dihydro-1H-indoles,

1985-11-27

1991-05-21

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514394, 514395, 546165, 546167, 548348, 548465, A61K 31415, A61K 3147, C07D40306, C07D40506

Patent

active

050175840

ABSTRACT:
2-(4,5-Dihydro-1H-imidazol-2-yl)-2,3-dihydro-1H-indoles, 2-(4,5-dihydro-1H-imidazol-2-yl)-1,2,3,4-tetrahydroquinolines and 2-(4,5-dihydro-1H-imidazol-2-yl)-1H-indoles, useful as antidepressant agents, are prepared by reacting a respective lower-alkyl 2,3-dihydro-1H-indole-2-carboxylate 1,2,3,4-tetrahydroquinoline-2-carboxylate or 1H-indole-2-carboxylate derivative with ethylenediamine or an N-lower-alkylethylenediamine in the presence of a Lewis-type acid.

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Bitny-Szachto et al., Acta Polon. Pharm., 34, (5), 527-530, (1977).

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