Synthetic bioadhesive

Details Synthetic bioadhesive Synthetic bioadhesive

1992-12-10

1994-12-20

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

514 2, 514 12, 514 14, 106124, 530300, 530324, 530327, 530350, C07K 1500, C07K 1300, C08L 8900, A61K 3702

Patent

active

053744314

ABSTRACT:
This invention pertains to a synthetic adhesive composition for use in aqueous environments. The composition comprises polypeptide chains having an .alpha.-helical structure in aqueous environments and capable of cohesive and adhesive interactions. The polypeptide chains comprise polar and apolar amino acids, the apolar and polar amino acids being arranged to define apolar and polar vertical spiraling stripes on the helix surface. The apolar stripes allow the polypeptide chains to aggregate into superhelical structures and the polar stripes allow interchain crosslinking within and between the superhelical structures.

REFERENCES:
patent: 4687740 (1987-08-01), Waite
patent: 4808702 (1989-02-01), Waite
Waite et al., Biochem. & Biophys. Res. Comm., vol. 96, No. 4, pp. 1554-1561; "The Bioadhesive of Mytilus Byssus: . . . ".
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Shoemaker et al., Nature, vol. 326, No. 6113 pp. 563-567 (1987); "Tests of the helix dipole model for . . . ".
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Crick, F.H.C. Acta Cryst (1953); "The packing of a-Helices:simple coiled-coils".
Dickerson et al., W. A. Benjamin Co., Inc., Menlo Park, Calif; (1969) "The structure and action of proteins".
Parry et al., J. Mol. Biol. (1977); "Structure of a-Keratin:structural implication . . . ".

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