Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-02-14
1999-12-28
Prouty, Rebecca E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530327, 530350, 514 12, 514 15, C07K 708, C07K 1447, A61K 3810, A61K 3817
Patent
active
060081953
ABSTRACT:
Novel antimicrobial peptides from bovine and murine neutrophils are provided. The peptides, designated bovine granulocyte peptide A (BGP-A) and murine granulocyte peptide A (MGP-A) were purified to homogeneity from peripheral blood granulocytes. The amino acid and nucleotide sequence of BGP-A and MGP-A are also provided. A synthetic version of BGP-A and MGP-A is also provided. The purified BGP-A peptide is shown to have antimicrobial activity indistinguishable from that of natural BGP-A. Synthetic carboxamidated analogs of BGP-A (BGP-A-amide) and MGP-A (MGP-A-amide) are also provided.
REFERENCES:
patent: 5459235 (1995-10-01), Selsted et al.
Diamond et al., "Airway epithelial cells are the site of expression of a Mammalian antimicrobial peptide gene", Proc. Natl. Acad. Sci., vol. 90, pp. 4596-4600, May, 1993.
Selsted et al., "Defensins in granules of phagocytic and non-phagocytic cells", Trends in Cell Biology, vol. 5, Mar. 1995.
Zanetti et al., The cDNA of the Neutrophil Antibiotic Bac5 Predicts a Pro-sequence Homologous to a Cysteine Proteinase Inhibitor That IS Common to Other Neutrophil Antibiotics, J. Of Biol. Chem., Jan. 5, 1993, vol. 268, No. 1, pp. 522-526.
Haile Lisa A.
Prouty Rebecca E.
The Regents of University of California
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