Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1993-02-03
1994-06-28
Rosen, Sam
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
435 79, 435 792, 436 86, 436 87, 436510, 436817, 436818, G01N 3353, G01N 3376
Patent
active
053246683
ABSTRACT:
A method and apparatus for determining if a pregnant woman is at significant risk of carrying a fetus with Down syndrome, The method comprises measuring the pregnant woman's maternal blood levels of the free beta subunit of human chorionic gonadotropin. The level of free beta subunit of human chorionic gonadotropin individually or with other markers may be compared to reference data. A computerized apparatus for making the determination preferably using a probability density function generated from a set of reference data by a linear discriminant analysis procedure is disclosed.
REFERENCES:
patent: 4016250 (1977-04-01), Saxena
patent: 4123224 (1978-10-01), Givner et al.
patent: 4565687 (1986-01-01), Khazaeli et al.
patent: 4874693 (1989-10-01), Bogart
patent: 5037305 (1991-08-01), Aleck
Arab et al., Biological Abstracts report of meeting held Oct. 12-15 1988, New Orleans, La. (39th annual meeting of Am. Soc. of Human Genetics).
Mooney et al., Clinica Chemica Acta, vol. 171, pp. 325-332 (1988).
Bogart et al., Biological Abstracts, vol. 85(7), abst No. 66203 (Apr. 1988).
Wisdom, G. B., Clin. Chem., vol. 22(8), pp. 1243-1255 (1978).
International Search Report from European Patent Office, mailed May 15, 1990, in PCT/US 90/00291 (based on U.S. Appl. Ser. No. 07/420,775 and others).
Am. J. Human Genetics (Suppl.), vol. 43, No. 3, Sep. 1988, H. Arab et al.: "Maternal serum beta human chorionic gonadotropin . . . " p. A225.
Prenatal Diagnosis, vol. 7, 1987, Mark H. Bogart et al. "Abnormal maternal serum chorionic . . . " pp. 623-630.
British Med. Journal, vol. 297, Oct. 1988, N.J., Wald et al.: "Maternal serum screening . . . " pp. 883-887.
Patent Abstracts of Japan, vol. 3, No. 143, C 66, abstract of JP 54-126723, publ. Feb. 10, 1979, Teikoku Zoki Seiyaku K. K.
American Journal of Obstetrics and Gynecology, vol. 48, No. 7, 1984, I. R. Merkatz et al.: "An association between low maternal serum . . . " pp. 886-890.
Ann. Endocrinol. (Paris) vol. 45(4-5), pp. 269-280, 1984, Gaspard, U. et al., "HCG and its Subunits in Normal and Pathological Pregnancies".
Acta Endocrinol.; 100(1), pp. 109-113, 1982 L'Hermite-Baleriaux, M. et al., "Alteration of free hCG Subunit Secretions in Ectopic Pregnancy".
Am. J. Human Genetics, vol. 43, No. 3, Sep. 1988, Bharathur et al.: "Amniotic fluid beta hCG levels Associated with Down syndrome and Other Chromosome Abnormalities" p. A226.
Conference Poster, Society of Perinatal Obstetricians, Feb. 7-8, 1992, Rotmensch et al., "Peptide Heterogeneity of Human Chorionic Gonadotropin (hCG) and Its .beta.-Subunit in Down Syndrome Pregnancies" p. 279.
The Lancet, Oct. 8, 1988, p. 851, Cuckle et al., "First-Trimester Biochemical Screening For Down Syndrome" pp. 851-852.
Prenatal Diagnosis, vol. 19, 245-251 (1990), Brock et al., "First-Trimester Maternal Serum Biochemical Indicators in Down Syndrome".
The Yale Journal of Biology and Medicine; 64(1991), 627-637, Cole et al., "The Biological and Clinical Significance of Nicks in Human Chorionic Gonadotropin and Its Free .beta.-Subunit".
Clin. Chem. 38/1, 26-33 (1992), Kardana et al., "Polypeptide Nicks Cause Erroneous Results in Assays of Human Chorionic Gonadotropin Free .beta.-Subunit".
Clin. Chem. 37/6, 809-814 (1991), Spencer, K. "Evaluation of an Assay of the Free .beta.-Subunit of Choriogonadotropin and Its Potential Value in Screening for Down's Syndrome".
J. Endocr. (1980), 84, 295-310, Storring, P. et al. "International Reference Preparation of Human Chorionic Gonadotrophin For Immunoassay: Potency Estimates in Various Bioassay and Protein Binding Assay Systems; And International Reference Preparations of the Alpha and .beta. Subunits for Human Chorionic Gonadotrophin for Immunoassay".
Am J Obstet Gynecol, vol. 155, No. 2, pp. 240-246, Aug. 1986, Macri, J. "Critical Issues in prenatal maternal serum Alpha-fetoprotein screening for genetic anomalies".
Am J Obstet Gynecol. vol. 148, pp. 241-254, Feb. 1984, Adams et al., "Clinical interpretation of maternal serum alpha-fetoprotein concentrations".
Clin. Chem. 36/4, 651-655 (1990), Thomas et al., "Human Choriogonadotropin (hCG): Comparisions between Determinations of Intact hCG, Free HCB .beta.-Subunit, Total hCG+.beta. in Serum during the First Half of High-Risk Pregnancy".
American Journal of Medical Genetics, 36:480-483 (1990), Ozturk et al., "Abnormal Maternal Serum Levels of Human Chorionic Gonadotropin Free Subunits in Trisomy 18".
American Journal of Obstetrics and Gynecology, vol. 163, No. 4, pp. 1248-1253, Oct 1990, Macri et al., "Maternal Serum Down Syndrome Screening: Free .beta.-Protein is a More Effective Marker than Human Chorionic Gonadotropin".
Endocrinology, vol. 126, No. 2, pp. 687-695 (1990), Puisieux et al., "Occurrence of Fragmentation of Free and Combined Forms of the .beta.-Subunit of Human Chorionic Gonadotropin".
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