Human Y-interferon signal peptide-tumor necrosis factor(TNF) gen

Details Human Y-interferon signal peptide-tumor necrosis factor(TNF) gen Human Y-interferon signal peptide-tumor necrosis factor(TNF) gen

1992-02-18

1994-06-28

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 691, 435 695, 435 697, 435 698, 4351723, 4351721, 4352401, 4353201, 536 231, 536 234, 536 232, 536 235, 536 2352, 935 23, 935 24, 935 27, 935 32, 935 34, 935 44, 935 47, 935 48, 935 66, 935 70, 935 71, C12N 510, C12N 1511, C12N 1528, C12N 1563

Patent

active

053246551

ABSTRACT:
A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes IL-2, multiple drug resistance protein, and TNF. Particularly disclosed is a DNA construct in which a gene encoding tumor necrosis factor (TNF) is directly linked to DNA encoding a human .gamma.-interferon signal peptide.

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Devos et al J Interferon Res vol. 4 pp. 461-468 1989.
Rosenberg, et al., 1988, The New England J. Med., 319(25):1676-1680.
Culver, et al., 1988, J. Cellular Biochemistry, Suppl. 12B:171 (Abstract No. H105).

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