Brain transcription factor, nucleic acids encoding same and uses

Details Brain transcription factor, nucleic acids encoding same and uses Brain transcription factor, nucleic acids encoding same and uses

1992-05-13

1994-06-28

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 235, 530350, C12P 2106, C07K 1300

Patent

active

053246381

ABSTRACT:
This invention provides an isolated, purified transcription factor expressed in the telencephalic region of the brain of a developing animal or in structures derived therefrom. Also provided is a nucleic acid molecule, e.g., an RNA or a DNA molecule encoding the transcription factor of this invention. Further provided are a pharmaceutical composition comprising the transcription factor and a method of correcting an animal's defective synthesis of the transcription factor which comprises administering to the patient an effective amount of the pharmaceutical composition. Still further provided are an expression vector containing this nucleic acid molecule, a host vector system containing the vector and a method of producing the transcription factor comprising growing the host vector system under suitable conditions.
This invention provides methods of diagnosing the overexpression of the transcription factor in tissue in which it is normally expressed and of detecting the presence of the factor in tissue.

REFERENCES:
Costa, R., et al. Multiple Hepatocyte-Enriched Nuclear Factors Function in the Regulation of Transthyretin and Alphal-Antitrypsin Genes. Molecular and Cellular Biology 9: 1415-1425, 1989 (Exhibit B).
Courey, A. J. and Tjian, R. Analysis of Spl In Vivo Reveals Multiple Transcriptional Domains, Including a Novel Glutamine-Rich Activation Motif.
Cell 55; 887-898, 1988 (Exhibit C).
Davis, C. A., et al. Expression of the Homeobox-Containing Gene En-2 Delineates a Specific Region of the Developing Mouse Brain. Genes & Development 2: 361-371, 1988 (Exhibit D).
Davis, C. A. and Joyner, A. L. Expression of the Homeo Box-Containing Genes En-1 and En-2 and the Proto-oncogene int-l Diverge During Mouse Development. Genes & Development 2: 1736-1744, 1988 (Exhibit E).
He, X., et al. Expression of a Large Family of POU-Domain Regulatory Genes in Mammalian Brain Development. Nature 340: 35-42, 1989 (Exhibit F).
He, X. and Rosenfeld, M. G. Mechanisms of Complex Transcriptional Regulation: Implications for Brain Development. Neuron 7: 183-196, 1991 (Exhibit G).
Kessel, M. and Gruss, P. Murine Developmental Control Genes. Science 249; 374-379, 1990 (Exhibit H).
Lai, E., et al. HNF-3A, A Hepatocyte-Enriched Transcription Factor of Novel Structure is Regulated Transcriptionally. Genes & Development 4: 1427-1436 1990 (Exhibit I).
Lai, E., et al. Hepatocyte Nuclear Factor 3 .alpha. Belongs to a Gene Family in Mammals that is Homologous to the Drosophila Homeotic Gene Fork Head. Genes & Development 5: 416-427 (Exhibit J).
Li, C., et al. Cloning of a Cellular Factor, Interleukin Binding Factor, that Binds to NFAT-Like Motifs in the Human Immunodeficiency Virus Long Terminal Repeat. Proc. Natl. Acad. Sci. USA 88: 7739-7743, 1991 (Exhibit K).
Mermod, N., et al. The Proline-Rich Transcriptional Activator of CTF/NF-1 is Distinct From the Replication and DNA Binding Domain. Cell 58: 741-753, 1991 (Exhibit L).
Mori, K., et al. Telencephalon-Specific Antigen Identified by Monoclonal Antibody, Proc. Natl. Acad. Sci. USA 84: 3921-3925, 1987 (Exhibit M).
Price, M., et al. A Mouse Gene Related to Distal-less Shows a Restricted Expression in the Development Forebrain. Nature 351: 748-750, 1991 (Exhibit N).
Weigel, D. and Jackel, H. The Fork Head Domain: A Novel DNA Binding Motif of Eucaryotic Transcription Factors?Cell 63: 455-456, 1990 (Exhibit O).
Wilkinson, D. G., et al. Segmental Expression of Hox-2 Homeobox-Containing Genes in the Developing Mouse Hindbrain. Nature 341: 405-409, 1989 (Exhibit P).

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