Sesbanimide and the use thereof in treating leukemic tumors

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D40500

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active

045323275

ABSTRACT:
A novel alkaloid compound named "sesbanimide" has been isolated from the tissue of a leguminous plant known as Sesbania drummondii. Sesbanimide is characterized by the structural formula ##STR1## and is effective as an antineoplastic agent in animals.

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Kinoshita et al., Abstract No. 75, 185th ACS National Meeting, Mar. 20-25, 1983.
R. G. Powell et al., "Antitumor Activity of Sesbania vesicaria, S. punicea, and S. drummondii Seed Extracts," Planta Med. 30(1): 1-8, (Aug. 1976).
R. G. Powell et al., "An Investigation of the Antitumor Activity of Sesbania drummondii," J. Nat. Prod. 44(1): 86-90, (Jan.-Feb. 1981).
"Sesbanimide-A New Antitumor Compound," Northern Regional Research Center (NRRC) Notes from the Director, Issue #1531, (Jan. 14, 1983).
R. G. Powell et al., "Sesbanimide, A Potent Antitumor Substance from Sesbania drummondii Seed," Abstract #74, Abstracts of Papers, 185th ACS National Meeting, Seattle, WA., Mar. 20-25, 1983.
R. G. Powell et al., "Sesbanimide, A Potent Antitumor Substance from Sesbania drummondii Seed," J. Amer. Chem. Soc. 105(11): 3739-3741, (1983).
R. G. Powell et al., "Sesbanimide," Proceedings of Symposium on Discovery and Development of Naturally Occurring Antitumor Agents, Frederick, MD., Jun. 27-29, 1983.

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