Benzoic acid derivatives and process for preparing the same

Details Benzoic acid derivatives and process for preparing the same Benzoic acid derivatives and process for preparing the same

1998-06-25

1999-12-28

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

556437, 556438, 556470, 514 63, C07F 708, C07F 710, C07F 718

Patent

active

RE0364770

ABSTRACT:
Benzoic acid derivatives represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen or lower-alkyl, R.sub.2 and R.sub.4 represent hydrogen, trimethylsilyl, or trimethylgermyl, R.sub.3 represents hydrogen, lower-alkyl, trimethylsilyl, or trimethylgermyl, R.sub.5 represents hydrogen, lower-alkyl, acetyl, or hydroxy, at least one of R.sub.2 and R.sub.3 being trimethylsilyl or trinethylgermyl, and R.sub.6 means hydroxy, lower-alkoxy, or a group of the formula --NR.sub.7 R.sub.8, wherein R.sub.7 and R.sub.8 mean hydrogen or lower-alkyl, and X represents a group of the formula --CONH--, --NHCO--, --COO--, --OCO--, --COCH.dbd.CH--, --COCH.dbd.C(OH), or --CH.dbd.CH--, which exhibit excellent effect as differentiation-inducing agents for neoplastic cells, especially leukemia cells, or a therapeutic agent for psoriasis or immune and inflammatory diseases, and a process for the preparation thereof, are disclosed.

REFERENCES:
patent: 4271084 (1981-06-01), Ishikawa et al.
patent: 4361579 (1982-11-01), Munakata et al.
patent: 4501702 (1985-02-01), Bulten et al.
patent: 4579961 (1986-04-01), Kakimoto
patent: 4772628 (1988-09-01), Kakimoto et al.
patent: 4798187 (1989-01-01), Hudson, Jr.
patent: 4808631 (1989-02-01), Klaus
patent: 4889715 (1989-12-01), Sawai et al.
patent: 4898882 (1990-02-01), Nagahama et al.
Abstract of 108th Annual Conference of Pharmaceutical Society of Japan, Apr. 4-6, 1988, p. 693, published Mar. 10, 1988.

Affiliated with

Also associated with

Rating

Benzoic acid derivatives and process for preparing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzoic acid derivatives and process for preparing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzoic acid derivatives and process for preparing the same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2373746