Process for preparing somatostatin analog

Details Process for preparing somatostatin analog Process for preparing somatostatin analog

1975-04-08

1978-12-19

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125S, 424177, C07C10352, A61K 3700

Patent

active

041305540

ABSTRACT:
Somatostatin analog, hereinafter designated des(Ala.sup.1 -Gly.sup.2)desaminocys.sup.3 -somatostatin, having the structure: ##STR1## is prepared by controlled stepwise procedures starting with individual amino acid components. This peptide has the property of lowering blood glucose, inhibiting gastric secretion and inhibiting growth hormone release in humans and animals.

REFERENCES:
patent: 3842066 (1974-10-01), McKinley et al.
patent: 3842067 (1974-10-01), Sarantakis
patent: 3882098 (1975-05-01), Sarantakis
patent: 3904594 (1975-09-01), Guillemin et al.
Berde et al., "Neurohypophysical Hormones and Similar Polypeptides," Handbook of Experimental Pharmacology, vol. 23, Springer-Verlag, Berlin, 1968, pp. 842-845, 856-857, 862.

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