Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-05-27
1994-10-18
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544402, C07D24104, A61K 31495
Patent
active
053568958
ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises; an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. Suitable agents contain an active nitrogen-containing group, such as a hydrazine group. Particular agents comprise aminoguanidine derivatives. the method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
REFERENCES:
patent: 4665192 (1987-05-01), Cerami
patent: 4758583 (1988-07-01), Cerami et al.
patent: 4908446 (1990-03-01), Ulrich et al.
patent: 5140048 (1992-08-01), Ulrich et al.
Cerami Anthony
Ulrich Peter C.
Springer David B.
The Rockefeller University
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