Antiviral pyrimidine nucleosides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 50, 514934, 536 41, A61K 3170, C07G 300

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053568826

ABSTRACT:
Pyrimidine 4'-thionucleosides of the formula I ##STR1## wherein Y is hydroxy or amino, and X is chloro, bromo, iodo, trifluoromethyl, C.sub.2-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 haloalkenyl or C.sub.2-6 alkynyl and physiologically functional derivatives thereof. These compounds have utility as anti-vital agents.

REFERENCES:
patent: 4211773 (1980-07-01), Lopez et al.
patent: 5055457 (1991-10-01), Schrinner et al.
patent: 5159067 (1992-10-01), Schinazi et al.
patent: 5215970 (1993-06-01), Datema et al.
European Patent Office Action mailed on Jan. 28, 1994.
Huang et al: Nucleosides & Nucleotides, 1993, "A Facile Synthesis of 4'-thio-2'-deoxypyrimidine Nucleosides and Preliminary Studies on Their Properties," pp. 139-147.
Reist et al., J. Org. Chem., vol. 33, pp. 189-192. Thio Sugars. "Synthesis of the Adenine Nucleosides of 4-thio-D-xylose and 4-thio-D-arabinose," (1968).
Reist et al, [No Journal Title Available], vol. 86, pp. 5658-5663, "Synthesis of 4-thio-D- and -L-ribofuranose and the corresponding adenine nucleosides," (1964).
Bellon et al, Biochem. Biophys. Res. Comm., vol. 184, 797-803, "Sugar Modified Oligonucleotide: Synthesis, nuclease resistance and base pairing of oligodeoxynucleoties containing 1-(4'-thio-.beta.-D-ribofuranosy)-thymine," (1992).
Bellon et al, Nucleosides & Nucleotides, vol. 11, pp. 1467-1479, "Efficient Synthesis of 4-thio-D-ribofuranose and some 4'-thioribonucleosides," (1992).
Clement & Berger, Med. Chem. Res., vol. 2, pp. 154-164, "Biological and antitumor activity of a series of 4'thio'-.beta.-D-ribofuranosy pyrimidines," (1992).
Dyson et al., Carbohydrate Research, vol. 216, pp. 237-248, "An improved synthesis of benzyl 3,5-di-O-benzyl-2-deoxy-1,3-dithio-D-erythro-pentofuranoside, an intermediate in the synthesis of 4'-thionucleosides," (1991).
Nayal & Whistler, Liebigs Ann. Chem., vol. 741, pp. 131-138, "Anomere methyl-2-desoxy-4-thio-D-erythro-pentofuranodise," (1970).
J. Med. Chem. 1991, 34, pp. 2361-2366, "Synthesis and Biological Activity of 2'-Deoxy-4'-thio Pyrimidine Nucleosides.sup.1 " Secrest III et al.
J. Med. Chem. 1991, 34, pp. 2782-2786, "The Synthesis and Antiviral Activity of Some 4'-Thio-2'deoxy Nucleoside Analogues" Dyson et al.
J. Chem. Soc. Chem. Commun., 1991, pp. 741-742, "The Synthesis and Antiviral Properties of E-5-(2-Bromovinyl)-4'-thio-2'-deoxyuridine" Dyson et al.
J. Chem. Soc. Chem. Commun., 1991, pp. 1421-1422, "Stereocontrolled Preparation of Cyclic Xanthate; a Novel Synthetic Route etc." Uenishi et al.
J. Med. Chem., 1992, 35, pp. 533-538, "Synthesis and Anti-HIV Activity of 4'-Thio-2',3'-dideoxynucleosides" Secrist III et al.
Fu et al.; Nucleic Acid Chemistry, vol. 1, 1978; pp. 317-323.
Fu et al.; J. Org. Chem., vol. 41, (24); 1976; pp. 3831-3834.
Whistler et al.; J. Org. Chem., vol. 36, No. 1; 1971; pp. 108-110.
Ototani et al.; J. Med. Chem., vol. 17, No. 5; 1974; pp. 535-537.
Bovek et al.; J. Med. Chem., vol. 18, No. 8; 1975; pp. 784-787.
Benz et al.; Liebigs Annalen der Chemie No. 8; 1984; pp. 1408-1423.
Kim et al.; Chem. Abstracts, vol. 84; 1986; 150879s; p. 575.
Pickering et al.; Chem. Abstracts, vol. 85; 1978; 191t; p. 12.
Kim et al.; Chem. Abstracts, vol. 83; 1975; 59198n; p. 543.
Miles et al.; Chem. Abstracts, vol. 73; 1970; 45760w.
Miles et al.; Chem. Abstracts, vol. 70; 1969; 72465y; p. 340.
Nishi et al.; Chem. Abstracts, vol. 106; 1987; 18966m; p. 648.
Anisuzzsman et al.; Chem. Abstracts, vol. 93; 1980; 47077r; p. 978.
Ritchie et al.; Chem. Abstracts, vol. 89; 6493x; p. 560.
Stoeckler et al.; Chem. Abstracts, vol. 92; 1980; 54127q; p. 276.
Ritchie et al.; Chem Abstracts, vol. 80; 1974; 3744h; p. 3749.
Anisuzzsman et al; Chem. Abstracts, vol. 79; 1973; 63102m; p. 174.
Bobek et al.; Chem. Abstracts, vol. 76; 1972; 122281g; p. 103.
Keyser et al.; Chem. Abstracts, vol. 92; 1980; 163934w; p. 600.
Bobek et al.; Chem. Abstracts, vol. 73; 1970; 4139g; pp. 356-357.
Reist et al.; Chem. Abstracts, vol. 68; 1968; 40003p; p. 3903.
Verhoaven et al.; Chem. Abstracts, vol. 110; 1989; 18139b; p. 20.
Miura et al.; Chem. Abstracts, vol. 106; 1987; 95695z; p. 30.
Smith et al.; Chem. Abstracts, vol. 86; 1977; 182968c; p. 19.
Adamson et al.; Chem. Abstracts, vol. 86; 1977; 133421k; p. 25.
Follmann et al.; Chem. Abstracts, vol. 83; 1975; 189442y; p. 138.
Wilson et al.; Chem. Abstracts, vol. 83; 1975; 97802n; p. 641.
Lau et al.; Chem. Abstracts, vol. 79; 1973; 13415v; p. 9.
Wilson et al.; Chem. Abstracts, vol. 75; 1971; 94595w; p. 11.
Hoffman et al.; Chem. Abstracts, vol. 73; 1970; 77542t; p. 400.
Chem. Abs. No. RN 6741-74-8.
Chem. Abs. No. RN 6741-72-6.
Chem. Abs. No. RN 6741-71-5.
Chem. Abs. No. RN 2500-79-0.

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