Monocyclic beta-lactams with antibacterial activity

Details Monocyclic beta-lactams with antibacterial activity Monocyclic beta-lactams with antibacterial activity

1976-11-15

1979-03-13

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546275, 260295L, 260302H, 260307A, 260307C, 260307G, 260308R, 260308D, 260326S, 260326N, 26032637, 2603322H, 2603472, 2603473, 424251, 424263, 424269, 424270, 424272, 424274, 424275, 424285, 544298, 544322, 544335, C07D20508, C07D40706, C07D40906, C07D41306

Patent

active

041443330

ABSTRACT:
A monocyclic .beta.-lactam containing a cis-.beta.-acylamino moiety as in the penicillin and cephalosporin antibacterials is disclosed. These compounds have antibacterial activity against a variety of Gram-positive and Gram-negative organisms. Intermediates useful for the preparation of these antibacterials are also disclosed.

REFERENCES:
patent: 3840556 (1975-10-01), Kukolja
patent: 3883517 (1975-05-01), Heusler et al.
patent: 3920696 (1975-11-01), Kukolja
patent: 3943123 (1976-03-01), Bose
patent: 4000154 (1976-12-01), Gleason et al.
Abdulla et al., J. Med. Chem., vol. 18, pp. 625-627 (1975).
Hashimoto et al., J. Am. Chem. Soc., vol. 98, pp. 3023-3025 (1976).

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