Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1978-07-17
1979-03-13
Schwartz, Gerald A.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260586R, C07C17700
Patent
active
041442741
ABSTRACT:
The present invention provides novel prostaglandin analogs wherein the C-2 carboxyl is replaced by alkylcarbonyl, i.e., a C-2 ketone. These novel 2-decarboxy-2-alkylcarbonyl-PG-type compounds are disclosed as improved gastrointestinal cytoprotective agents, being devoid or substantially devoid of other prostaglandin-type effects (e.g., smooth muscle or cardiovascular).
REFERENCES:
patent: 3931296 (1976-01-01), Hayashi et al.
patent: 3953435 (1976-04-01), Hayashi et al.
patent: 4066751 (1978-01-01), Hayashi et al.
Derwent Farmdoc CPI No. 93049X.
Armitage Robert A.
Schwartz Gerald A.
The Upjohn Company
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