Porphine-carbohydrate-fatty acid complexes as synthetic respirat

Details Porphine-carbohydrate-fatty acid complexes as synthetic respirat Porphine-carbohydrate-fatty acid complexes as synthetic respirat

1980-11-28

1981-12-22

Randolph, John D.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 51, 536112, 536113, 260314, A61K 3140, C07D48722, C09B 4700

Patent

active

043070841

ABSTRACT:
An aqueous, biologically-compatible, reversible, oxygen-carrying system comprising a novel metallated porphine-carbohydrate-fatty acid complex, particularly a novel tetra-(p-carboxyphenyl)porphine-iron(II)-dextran-octanoate complex, useful as a synthetic respiratory pigment, and a method for preparing same. The complexes may be dissolved in a suitable electrolyte and used as a substitute for red blood cells.

REFERENCES:
Datta-Gupta et al., J. Heterocyclic Chem. vol. 3, pp. 495-502 (1966).
Aronson et al., Chem. Abstracts, vol. 80,. abst. 12155u (1974).
Messmer et al., Chem. Abstracts, vol. 82, abst. 68435 (1975).
Tsuchida et al., Biochim. Biophys. Acta, vol. 427, pp. 520-529 (1976).
Jones et al., Chem. Reviews, vol. 79, pp. 139 to 175 (1979) (note especially pp. 140-147).

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