Perfusate redox potential controller

Chemistry: molecular biology and microbiology – Apparatus

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204195F, 204195L, 204195T, 435 1, 435 3, 435289, A01N 102

Patent

active

042999197

ABSTRACT:
Apparatus for controlling the redox potential of a perfusate for use in the preservation of organs to be transplanted and the like, which apparatus includes first and second cells, a membrane with a submicron pore size disposed in openings between the cells, first and second electrodes disposed in the first and second cells respectively, a reference electrode adapted to be in electrical contact with the perfusate, and circuitry for detecting the redox potential of the perfusate as measured against the reference electrode and for maintaining the redox potential at a predetermined level by causing current to flow between the first and second electrodes through the perfusate when the measured redox potential differs from the predetermined level. The first cell has first and second ports for ingress and egress of the perfusate into and out of the first cell. The membrane allows electrical current to flow between the first and second cells but prevents particles larger than the pore size from passing from one cell to the other.

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Codd, Jellinek et al., "Redox Maintenance in Restoration of Organ Viability", 22 Journal of Surgical Research 585-592 (1977).

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