Pyridine-substituted benzenemethanamine derivatives

Details Pyridine-substituted benzenemethanamine derivatives Pyridine-substituted benzenemethanamine derivatives

1994-05-12

1996-01-02

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546287, 546288, 546296, 546297, 546307, 546309, 546310, 546112, 546141, 546143, 546157, 546159, 546162, 546183, 5483721, 5483714, 549 68, C07D21357, C07D21369, C07D21372, C07D21378

Patent

active

054809975

ABSTRACT:
##STR1## The present invention is concerned with antiretroviral (e.g. anti-HIV-1) compounds having formula (I), wherein R.sup.1 and R.sup.2 each independently are halo or methyl; R.sup.3 is hydrogen, halo, nitro or trifluoromethyl; R.sup.4 is trifluoromethyl or methylcarbonyl; or a radical --C(.dbd.X)--NR.sup.5 R.sup.6 wherein X is O or S, and R.sup.and R.sup.6 each independently are hydrogen or C.sub.1-4 alkyl; or a radical -Alk-R.sup.7, wherein Alk is C.sub.1-4 alkanediyl; and R.sup.7 is hydrogen or hydroxy; Het is a heterocycle radical of formulae (a); (b); (c); (d) or (e). Pharmaceutical compositions containing said compounds of formula (I) and processes of preparing said compounds and compositions.

REFERENCES:
patent: 4246429 (1981-01-01), Van Daele

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