Antifungal amide and urea derivatives of (3-amino-2-aryl-2-hydro

Details Antifungal amide and urea derivatives of (3-amino-2-aryl-2-hydro Antifungal amide and urea derivatives of (3-amino-2-aryl-2-hydro

1983-06-03

1984-11-13

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424250, 424263, 424267, 424269, 544298, 544310, 544316, 544317, 544318, 544319, 544321, 544326, 544328, 544331, 544333, 544405, 546210, 546276, 548112, 548229, 548262, A01N 4364, C07D24908, C07D40112, C07D40312

Patent

active

044825587

ABSTRACT:
Compounds of the general formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R is naphthyl, biphenylyl, phenyl or substituted phenyl; and R.sup.1 is ##STR2## where X is O or S, R.sup.2 is H, or C.sub.1 -C.sub.4 alkyl and R.sup.3 is H, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, optionally mono- or disubstituted phenyl, benzyl or Het and Het is pyridyl, pyrimidinyl or pyrazinyl; said substituents being halo, CF.sub.3, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or hydroxy, or R.sup.2 and R.sup.3 taken together complete a 1-pyrrolidinyl or piperidino ring; methods for their use in combatting fungal infections in plants and animals, including humans; pharmaceutical and agricultural compositions containing them and intermediates useful in their preparation.

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